Mechanism for Recognition of an Unusual Mycobacterial Glycolipid by the Macrophage Receptor Mincle

Binding of the macrophage lectin mincle to trehalose dimycolate, a key glycolipid virulence factor on the surface of Mycobacterium tuberculosis and Mycobacterium bovis, initiates responses that can lead both to toxicity and to protection of these pathogens from destruction. Crystallographic structur...

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Bibliographic Details
Main Authors: Feinberg, Hadar, Jégouzo, Sabine A. F., Rowntree, Thomas J. W., Guan, Yue, Brash, Matthew A., Taylor, Maureen E., Weis, William I., Drickamer, Kurt
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789947/
https://ncbi.nlm.nih.gov/pubmed/23960080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.497149
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