Mechanism for Recognition of an Unusual Mycobacterial Glycolipid by the Macrophage Receptor Mincle

Binding of the macrophage lectin mincle to trehalose dimycolate, a key glycolipid virulence factor on the surface of Mycobacterium tuberculosis and Mycobacterium bovis, initiates responses that can lead both to toxicity and to protection of these pathogens from destruction. Crystallographic structur...

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Autors principals: Feinberg, Hadar, Jégouzo, Sabine A. F., Rowntree, Thomas J. W., Guan, Yue, Brash, Matthew A., Taylor, Maureen E., Weis, William I., Drickamer, Kurt
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Glycobiology and Extracellular Matrices
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789947/
https://ncbi.nlm.nih.gov/pubmed/23960080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.497149
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