Direct Monitoring of the Strand Passage Reaction of DNA Topoisomerase II Triggers Checkpoint Activation

By necessity, the ancient activity of type II topoisomerases co-evolved with the double-helical structure of DNA, at least in organisms with circular genomes. In humans, the strand passage reaction of DNA topoisomerase II (Topo II) is the target of several major classes of cancer drugs which both po...

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Bibliographic Details
Main Authors: Furniss, Katherine L., Tsai, Hung-Ji, Byl, Jo Ann W., Lane, Andrew B., Vas, Amit C., Hsu, Wei-Shan, Osheroff, Neil, Clarke, Duncan J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789831/
https://ncbi.nlm.nih.gov/pubmed/24098144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003832
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