Comparing Zinc Finger Nucleases and Transcription Activator-Like Effector Nucleases for Gene Targeting in Drosophila

Zinc-finger nucleases have proven to be successful as reagents for targeted genome manipulation in Drosophila melanogaster and many other organisms. Their utility has been limited, however, by the significant failure rate of new designs, reflecting the complexity of DNA recognition by zinc fingers....

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Bibliografske podrobnosti
Main Authors: Beumer, Kelly J., Trautman, Jonathan K., Christian, Michelle, Dahlem, Timothy J., Lake, Cathleen M., Hawley, R. Scott, Grunwald, David J., Voytas, Daniel F., Carroll, Dana
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2013
Teme:
Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789796/
https://ncbi.nlm.nih.gov/pubmed/23979928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.113.007260
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