TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis

Thioredoxin-interacting protein (TXNIP) has multiple functions, including tumor suppression and involvement in cell proliferation and apoptosis. However, its role in the inflammatory process remains unclear. In this report, we demonstrate that Txnip(−/−) mice are significantly more susceptible to li...

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Huvudupphovsmän: Park, Young-Jun, Yoon, Sung-Jin, Suh, Hyun-Woo, Kim, Dong Oh, Park, Jeong-Ran, Jung, Haiyoung, Kim, Tae-Don, Yoon, Suk Ran, Min, Jeong-Ki, Na, Hee-Jun, Lee, Seon-Jin, Lee, Hee Gu, Lee, Young Ho, Lee, Hee-Bong, Choi, Inpyo
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789754/
https://ncbi.nlm.nih.gov/pubmed/24098117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003646
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