TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis

Thioredoxin-interacting protein (TXNIP) has multiple functions, including tumor suppression and involvement in cell proliferation and apoptosis. However, its role in the inflammatory process remains unclear. In this report, we demonstrate that Txnip(−/−) mice are significantly more susceptible to li...

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Detalhes bibliográficos
Main Authors: Park, Young-Jun, Yoon, Sung-Jin, Suh, Hyun-Woo, Kim, Dong Oh, Park, Jeong-Ran, Jung, Haiyoung, Kim, Tae-Don, Yoon, Suk Ran, Min, Jeong-Ki, Na, Hee-Jun, Lee, Seon-Jin, Lee, Hee Gu, Lee, Young Ho, Lee, Hee-Bong, Choi, Inpyo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789754/
https://ncbi.nlm.nih.gov/pubmed/24098117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003646
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