Oxidative stress-mediated TXNIP loss causes RPE dysfunction

The disruption of the retinal pigment epithelium (RPE), for example, through oxidative damage, is a common factor underlying age-related macular degeneration (AMD). Aberrant autophagy also contributes to AMD pathology, as autophagy maintains RPE homeostasis to ensure blood–retinal barrier (BRB) inte...

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Pubblicato in:Exp Mol Med
Autori principali: Ji Cho, Min, Yoon, Sung-Jin, Kim, Wooil, Park, Jongjin, Lee, Jangwook, Park, Jong-Gil, Cho, Young-Lai, Hun Kim, Jeong, Jang, Hyejin, Park, Young-Jun, Lee, Sang-Hyun, Min, Jeong-Ki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802648/
https://ncbi.nlm.nih.gov/pubmed/31615975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0327-y
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