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Improved Detection of Rare HIV-1 Variants using 454 Pyrosequencing
454 pyrosequencing, a massively parallel sequencing (MPS) technology, is often used to study HIV genetic variation. However, the substantial mismatch error rate of the PCR required to prepare HIV-containing samples for pyrosequencing has limited the detection of rare variants within viral population...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3788733/ https://ncbi.nlm.nih.gov/pubmed/24098517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076502 |
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