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Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies
Wnt signaling stabilizes β-catenin through the LRP6 receptor signaling complex, which antagonizes the β-catenin destruction complex. The Axin scaffold and associated glycogen synthase kinase-3 (GSK3) have central roles in both assemblies, but the transduction mechanism from the receptor to the destr...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3788643/ https://ncbi.nlm.nih.gov/pubmed/23579495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1232389 |
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