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Suppression of Alzheimer’s Disease-Related Phenotypes by Geranylgeranylacetone in Mice
Amyloid-β peptide (Aβ) plays an important role in the pathogenesis of Alzheimer’s disease (AD). Aβ is generated by the secretase-mediated proteolysis of β-amyloid precursor protein (APP), and cleared by enzyme-mediated degradation and phagocytosis. Transforming growth factor (TGF)-β1 stimulates this...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3788141/ https://ncbi.nlm.nih.gov/pubmed/24098472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076306 |
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