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Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis.

Drug-induced interstitial lung disease (ILD), particularly pulmonary fibrosis, is of serious clinical concern. Gefitinib, a tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR), is beneficial as a drug for treating non-small cell lung cancer; however, this drug induces ILD and th...

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Detalhes bibliográficos
Main Authors: Takushi Namba, Ken-ichiro Tanaka, Tatsuya Hoshino, Arata Azuma, Tohru Mizushima
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2011-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3212557?pdf=render
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