Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia

BACKGROUND: Doxorubicin is associated with progressive cardiac dysfunction, possibly by forming doxorubicin-iron complexes leading to free-radical injury. We determined the frequency of hemochromatosis (HFE) gene mutations associated with hereditary hemochromatosis and their relationship with doxoru...

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Autors principals: Lipshultz, Steven E., Lipsitz, Stuart R., Kutok, Jeffery L., Miller, Tracie L., Colan, Steven D., Neuberg, Donna S., Stevenson, Kristen E., Fleming, Mark D., Sallan, Stephen E., Franco, Vivian I., Henkel, Jacqueline M., Asselin, Barbara L., Athale, Uma H., Clavell, Luis A., Michon, Bruno, Laverdiere, Caroline, Larsen, Eric, Kelly, Kara M., Silverman, Lewis B.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788065/
https://ncbi.nlm.nih.gov/pubmed/23861158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28256
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