Continuous Versus Bolus Infusion of Doxorubicin in Children With ALL: Long-term Cardiac Outcomes

BACKGROUND AND OBJECTIVES: Doxorubicin, effective against many malignancies, is limited by cardiotoxicity. Continuous-infusion doxorubicin, compared with bolus-infusion, reduces early cardiotoxicity in adults. Its effectiveness in reducing late cardiotoxicity in children remains uncertain. We determ...

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Autori principali: Lipshultz, Steven E., Miller, Tracie L., Lipsitz, Stuart R., Neuberg, Donna S., Dahlberg, Suzanne E., Colan, Steven D., Silverman, Lewis B., Henkel, Jacqueline M., Franco, Vivian I., Cushman, Laura L., Asselin, Barbara L., Clavell, Luis A., Athale, Uma, Michon, Bruno, Laverdière, Caroline, Schorin, Marshall A., Larsen, Eric, Usmani, Naheed, Sallan, Stephen E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Academy of Pediatrics 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507254/
https://ncbi.nlm.nih.gov/pubmed/23166343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1542/peds.2012-0727
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