Continuous Versus Bolus Infusion of Doxorubicin in Children With ALL: Long-term Cardiac Outcomes

BACKGROUND AND OBJECTIVES: Doxorubicin, effective against many malignancies, is limited by cardiotoxicity. Continuous-infusion doxorubicin, compared with bolus-infusion, reduces early cardiotoxicity in adults. Its effectiveness in reducing late cardiotoxicity in children remains uncertain. We determ...

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Main Authors: Lipshultz, Steven E., Miller, Tracie L., Lipsitz, Stuart R., Neuberg, Donna S., Dahlberg, Suzanne E., Colan, Steven D., Silverman, Lewis B., Henkel, Jacqueline M., Franco, Vivian I., Cushman, Laura L., Asselin, Barbara L., Clavell, Luis A., Athale, Uma, Michon, Bruno, Laverdière, Caroline, Schorin, Marshall A., Larsen, Eric, Usmani, Naheed, Sallan, Stephen E.
Format: Artigo
Sprog:Inglês
Udgivet: American Academy of Pediatrics 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507254/
https://ncbi.nlm.nih.gov/pubmed/23166343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1542/peds.2012-0727
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