Continuous Versus Bolus Infusion of Doxorubicin in Children With ALL: Long-term Cardiac Outcomes

BACKGROUND AND OBJECTIVES: Doxorubicin, effective against many malignancies, is limited by cardiotoxicity. Continuous-infusion doxorubicin, compared with bolus-infusion, reduces early cardiotoxicity in adults. Its effectiveness in reducing late cardiotoxicity in children remains uncertain. We determ...

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Autors principals: Lipshultz, Steven E., Miller, Tracie L., Lipsitz, Stuart R., Neuberg, Donna S., Dahlberg, Suzanne E., Colan, Steven D., Silverman, Lewis B., Henkel, Jacqueline M., Franco, Vivian I., Cushman, Laura L., Asselin, Barbara L., Clavell, Luis A., Athale, Uma, Michon, Bruno, Laverdière, Caroline, Schorin, Marshall A., Larsen, Eric, Usmani, Naheed, Sallan, Stephen E.
Format: Artigo
Idioma:Inglês
Publicat: American Academy of Pediatrics 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507254/
https://ncbi.nlm.nih.gov/pubmed/23166343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1542/peds.2012-0727
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