Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia

BACKGROUND: Doxorubicin is associated with progressive cardiac dysfunction, possibly by forming doxorubicin-iron complexes leading to free-radical injury. We determined the frequency of hemochromatosis (HFE) gene mutations associated with hereditary hemochromatosis and their relationship with doxoru...

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Main Authors: Lipshultz, Steven E., Lipsitz, Stuart R., Kutok, Jeffery L., Miller, Tracie L., Colan, Steven D., Neuberg, Donna S., Stevenson, Kristen E., Fleming, Mark D., Sallan, Stephen E., Franco, Vivian I., Henkel, Jacqueline M., Asselin, Barbara L., Athale, Uma H., Clavell, Luis A., Michon, Bruno, Laverdiere, Caroline, Larsen, Eric, Kelly, Kara M., Silverman, Lewis B.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788065/
https://ncbi.nlm.nih.gov/pubmed/23861158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28256
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