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Exploitation of latent protein allostery enables the evolution of novel and divergent MAP kinase regulation
Allosteric interactions provide precise spatiotemporal control over signaling proteins, but how allosteric activators and their targets co-evolve is poorly understood. Here, we trace the evolution of two allosteric activator motifs within the yeast scaffold protein Ste5 that specifically target the...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3787944/ https://ncbi.nlm.nih.gov/pubmed/23953117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.07.019 |
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