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Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution
The Ras-superfamily GTPases are central controllers of cell proliferation and morphology. Ras signaling is mediated by a system of interacting molecules: upstream enzymes (GEF/GAP) regulate Ras’s ability to recruit multiple competing downstream effectors. We developed a multiplexed, multi-turnover a...
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| Publicat a: | eLife |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4775219/ https://ncbi.nlm.nih.gov/pubmed/26765565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12435 |
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