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H(4)octapa-Trastuzumab: Versatile Acyclic Chelate System for (111)In and (177)Lu Imaging and Therapy

[Image: see text] A bifunctional derivative of the versatile acyclic chelator H(4)octapa, p-SCNBn- H(4)octapa, has been synthesized for the first time. The chelator was conjugated to the HER2/neu-targeting antibody trastuzumab and labeled in high radiochemical purity and specific activity with the r...

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Bibliografski detalji
Glavni autori: Price, Eric W., Zeglis, Brian M., Cawthray, Jacqueline F., Ramogida, Caterina F., Ramos, Nicholas, Lewis, Jason S., Adam, Michael J., Orvig, Chris
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787943/
https://ncbi.nlm.nih.gov/pubmed/23901833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4049493
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