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H(6)phospa-Trastuzumab: Bifunctional Methylenephosphonate-based Chelator with (89)Zr, (111)In and (177)Lu
The acyclic chelator H(6)phospa and the bifunctional derivative p-SCN-Bn-H(6)phospa have been synthesized using nosyl protection chemistry and evaluated with (89)Zr, (111)In, and (177)Lu. The p-SCN-Bn-H(6)phospa derivative was successfully conjugated to trastuzumab with isotopic dilution assays indi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3872121/ https://ncbi.nlm.nih.gov/pubmed/24104523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3dt51940f |
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