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T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor

Essential tremor is a common disorder that lacks molecular targets for therapeutic development. T-type calcium channel activation has been postulated to underlie rhythmicity in the olivo-cerebellar system that is implicated in essential tremor. We therefore tested whether compounds that antagonize T...

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Detalhes bibliográficos
Main Authors: Handforth, Adrian, Homanics, Gregg E., Covey, Douglas F., Krishnan, Kathiresan, Lee, Jae Yeol, Sakimura, Kenji, Martin, Fredricka C., Quesada, Arnulfo
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787716/
https://ncbi.nlm.nih.gov/pubmed/20547167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2010.05.012
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