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Design and Synthesis of (13S)-Methyl-Substituted Arachidonic Acid Analogues: Templates for Novel Endocannabinoids

Two novel methyl-substituted arachidonic acid derivatives were prepared in an enantioselective manner from commercially available chiral building blocks, and were found to be excellent templates for the development of (13S)-methyl-substituted anandamide analogues. One of the compounds synthesized, n...

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Detalhes bibliográficos
Main Authors: Papahatjis, Demetris P., Nahmias, Victoria R., Nikas, Spyros P., Schimpgen, Marion, Makriyannis, Alexandros
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786736/
https://ncbi.nlm.nih.gov/pubmed/20187040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.200902880
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