13-Methylarachidonic Acid Is a Positive Allosteric Modulator of Endocannabinoid Oxygenation by Cyclooxygenase

Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and the endocannabinoids 2-arachidonoylglycerol (2-AG) and arachidonylethanolamide to prostaglandins, prostaglandin glyceryl esters, and prostaglandin ethanolamides, respectively. A structural homodimer, COX-2 acts as a conformational heterod...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kudalkar, Shalley N., Nikas, Spyros P., Kingsley, Philip J., Xu, Shu, Galligan, James J., Rouzer, Carol A., Banerjee, Surajit, Ji, Lipin, Eno, Marsha R., Makriyannis, Alexandros, Marnett, Lawrence J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367288/
https://ncbi.nlm.nih.gov/pubmed/25648895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.634014
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