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Cyclooxygenases: structural and functional insights

Cyclooxygenase (COX; prostaglandin G/H synthase, EC 1.14.99.1) catalyzes the first two steps in the biosynthesis of prostaglandins (PGs). The two COX isoforms COX-1 and COX-2 are the targets of the widely used nonsteroidal anti-inflammatory drugs, indicating a role for these enzymes in pain, fever,...

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Bibliographic Details
Main Authors: Rouzer, Carol A., Marnett, Lawrence J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674713/
https://ncbi.nlm.nih.gov/pubmed/18952571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.R800042-JLR200
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