A Strategy for Synthesis of Pathogenic Human Immunoglobulin Free Light Chains in E. coli

Monoclonal immunoglobulin light chains are normally synthesized in excess compared to the heavy chain partners and can be detected in serum and urine (“free” LC). Occasionally free LC are per se cause of organ toxicity, as in free LC-related disorders. In AL amyloidosis, the most common of these con...

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Autors principals: Rognoni, Paola, Lavatelli, Francesca, Casarini, Simona, Palladini, Giovanni, Verga, Laura, Pedrazzoli, Paolo, Valentini, Giovanna, Merlini, Giampaolo, Perfetti, Vittorio
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785434/
https://ncbi.nlm.nih.gov/pubmed/24086679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076022
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