Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

Systemic light chain amyloidosis (AL)  is a life-threatening disease caused by aggregation and deposition of monoclonal immunoglobulin light chains (LC) in target organs. Severity of heart involvement is the most important factor determining prognosis. Here, we report the 4.0 Å resolution cryo-elect...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Swuec, Paolo, Lavatelli, Francesca, Tasaki, Masayoshi, Paissoni, Cristina, Rognoni, Paola, Maritan, Martina, Brambilla, Francesca, Milani, Paolo, Mauri, Pierluigi, Camilloni, Carlo, Palladini, Giovanni, Merlini, Giampaolo, Ricagno, Stefano, Bolognesi, Martino
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6427027/
https://ncbi.nlm.nih.gov/pubmed/30894521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09133-w
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