A Strategy for Synthesis of Pathogenic Human Immunoglobulin Free Light Chains in E. coli

Monoclonal immunoglobulin light chains are normally synthesized in excess compared to the heavy chain partners and can be detected in serum and urine (“free” LC). Occasionally free LC are per se cause of organ toxicity, as in free LC-related disorders. In AL amyloidosis, the most common of these con...

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Detalhes bibliográficos
Main Authors: Rognoni, Paola, Lavatelli, Francesca, Casarini, Simona, Palladini, Giovanni, Verga, Laura, Pedrazzoli, Paolo, Valentini, Giovanna, Merlini, Giampaolo, Perfetti, Vittorio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785434/
https://ncbi.nlm.nih.gov/pubmed/24086679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076022
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