Phosphorylation Regulates NCC Stability and Transporter Activity In Vivo

A T60M mutation in the thiazide-sensitive sodium chloride cotransporter (NCC) is common in patients with Gitelman’s syndrome (GS). This mutation prevents Ste20-related proline and alanine-rich kinase (SPAK)/oxidative stress responsive kinase-1 (OSR1)–mediated phosphorylation of NCC and alters NCC tr...

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Autori principali: Yang, Sung-Sen, Fang, Yu-Wei, Tseng, Min-Hua, Chu, Pei-Yi, Yu, I-Shing, Wu, Han-Chung, Lin, Shu-Wha, Chau, Tom, Uchida, Shinichi, Sasaki, Sei, Lin, Yuh-Feng, Sytwu, Huey-Kang, Lin, Shih-Hua
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2013
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785268/
https://ncbi.nlm.nih.gov/pubmed/23833262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012070742
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