Engineered antibody Fc variant with selectively enhanced FcγRIIb binding over both FcγRIIa(R131) and FcγRIIa(H131)

Engaging inhibitory FcγRIIb by Fc region has been recently reported to be an attractive approach for improving the efficacy of antibody therapeutics. However, the previously reported S267E/L328F variant with enhanced binding affinity to FcγRIIb, also enhances binding affinity to FcγRIIa(R131) alloty...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Mimoto, F., Katada, H., Kadono, S., Igawa, T., Kuramochi, T., Muraoka, M., Wada, Y., Haraya, K., Miyazaki, T., Hattori, K.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785249/
https://ncbi.nlm.nih.gov/pubmed/23744091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzt022
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki