Novel asymmetrically engineered antibody Fc variant with superior FcγR binding affinity and specificity compared with afucosylated Fc variant

Fc engineering is a promising approach to enhance the antitumor efficacy of monoclonal antibodies (mAbs) through antibody-dependent cell-mediated cytotoxicity (ADCC). Glyco- and protein-Fc engineering have been employed to enhance FcγR binding and ADCC activity of mAbs; the drawbacks of previous app...

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Main Authors: Mimoto, Futa, Igawa, Tomoyuki, Kuramochi, Taichi, Katada, Hitoshi, Kadono, Shojiro, Kamikawa, Takayuki, Shida-Kawazoe, Meiri, Hattori, Kunihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893233/
https://ncbi.nlm.nih.gov/pubmed/23406628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.23452
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