Engineered antibody Fc variant with selectively enhanced FcγRIIb binding over both FcγRIIa(R131) and FcγRIIa(H131)

Engaging inhibitory FcγRIIb by Fc region has been recently reported to be an attractive approach for improving the efficacy of antibody therapeutics. However, the previously reported S267E/L328F variant with enhanced binding affinity to FcγRIIb, also enhances binding affinity to FcγRIIa(R131) alloty...

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Detalhes bibliográficos
Main Authors: Mimoto, F., Katada, H., Kadono, S., Igawa, T., Kuramochi, T., Muraoka, M., Wada, Y., Haraya, K., Miyazaki, T., Hattori, K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785249/
https://ncbi.nlm.nih.gov/pubmed/23744091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzt022
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