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An Activation State-Selective Kinase Inhibitor Assay Based on Ion Mobility-Mass Spectrometry
The discovery of activation state dependent kinase inhibitors, which bind specifically to the inactive conformation of the protein, is considered to be a promising pathway to improved cancer treatments. Identifying such inhibitors is challenging, however, because they can have K(d) values similar to...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3784979/ https://ncbi.nlm.nih.gov/pubmed/23845095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac4012655 |
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