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An Activation State-Selective Kinase Inhibitor Assay Based on Ion Mobility-Mass Spectrometry

The discovery of activation state dependent kinase inhibitors, which bind specifically to the inactive conformation of the protein, is considered to be a promising pathway to improved cancer treatments. Identifying such inhibitors is challenging, however, because they can have K(d) values similar to...

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Autores principales: Rabuck, Jessica N., Hyung, Suk-Joon, Ko, Kristin S., Fox, Christel C., Soellner, Matthew B., Ruotolo, Brandon T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784979/
https://ncbi.nlm.nih.gov/pubmed/23845095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac4012655
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