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Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues

Epidermal growth factor receptor (EGFR) ligands undergo a complex series of processing events during their maturation to active signaling proteins. Like its mammalian homologs, the predominant Drosophila EGFR ligand Spitz is produced as a transmembrane pro-protein. In the secretory pathway, Spitz is...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Steinhauer, Josefa, Liu, Hui Hua, Miller, Eli, Treisman, Jessica E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784823/
https://ncbi.nlm.nih.gov/pubmed/23902690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.131169
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