Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor

The phosphate-dependent transition between enzymatically inert dimers into catalytically capable tetramers has long been the accepted mechanism for the glutaminase activation. Here, we demonstrate that activated glutaminase C (GAC) self-assembles into a helical, fiber-like double-stranded oligomer a...

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Detalhes bibliográficos
Main Authors: Ferreira, Amanda Petrina Scotá, Cassago, Alexandre, Gonçalves, Kaliandra de Almeida, Dias, Marília Meira, Adamoski, Douglas, Ascenção, Carolline Fernanda Rodrigues, Honorato, Rodrigo Vargas, de Oliveira, Juliana Ferreira, Ferreira, Igor Monteze, Fornezari, Camila, Bettini, Jefferson, Oliveira, Paulo Sérgio Lopes, Paes Leme, Adriana Franco, Portugal, Rodrigo Villares, Ambrosio, Andre Luis Berteli, Dias, Sandra Martha Gomes
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784714/
https://ncbi.nlm.nih.gov/pubmed/23935106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.501346
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