Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition–resistant triple-negative breast cancer cells

Triple-negative breast cancers (TNBCs) lack progesterone and estrogen receptors and do not have amplified human epidermal growth factor receptor 2, the main therapeutic targets for managing breast cancer. TNBCs have an altered metabolism, including an increased Warburg effect and glutamine dependenc...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: dos Reis, Larissa Menezes, Adamoski, Douglas, Ornitz Oliveira Souza, Rodolpho, Rodrigues Ascenção, Carolline Fernanda, Sousa de Oliveira, Krishina Ratna, Corrêa-da-Silva, Felipe, Malta de Sá Patroni, Fábio, Meira Dias, Marília, Consonni, Sílvio Roberto, Mendes de Moraes-Vieira, Pedro Manoel, Silber, Ariel Mariano, Dias, Sandra Martha Gomes
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579458/
https://ncbi.nlm.nih.gov/pubmed/31040181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008180
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