Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

Glutamine is an essential nutrient for cancer cell proliferation, especially in the context of citric acid cycle anaplerosis. In this manuscript we present results that collectively demonstrate that, of the three major mammalian glutaminases identified to date, the lesser studied splice variant of t...

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Detalhes bibliográficos
Main Authors: Cassago, Alexandre, Ferreira, Amanda P. S., Ferreira, Igor M., Fornezari, Camila, Gomes, Emerson R. M., Greene, Kai Su, Pereira, Humberto M., Garratt, Richard C., Dias, Sandra M. G., Ambrosio, Andre L. B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268272/
https://ncbi.nlm.nih.gov/pubmed/22228304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112495109
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