Akt Phosphorylates the Transcriptional Repressor Bmi1 to Block Its Effects on the Tumor-Suppressing Ink4a-Arf Locus

The Polycomb group protein Bmi1 is a transcriptional silencer of the Ink4a-Arf locus, which encodes the cell cycle regulator p16(Ink4a) and the tumor suppressor p19(Arf). Bmi1 plays a key role in oncogenesis and stem cell self-renewal. We report that phosphorylation of human Bmi1 at Ser(316) by Akt...

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Bibliografski detalji
Glavni autori: Liu, Yan, Liu, Fan, Yu, Hao, Zhao, Xinyang, Sashida, Goro, Deblasio, Anthony, Harr, Michael, She, Qing-Bai, Chen, Zhenbang, Lin, Hui-Kuan, Di Giandomenico, Silvana, Elf, Shannon E., Yang, Youyang, Miyata, Yasuhiko, Huang, Gang, Menendez, Silvia, Mellinghoff, Ingo K., Rosen, Neal, Pandolfi, Pier Paolo, Hedvat, Cyrus V., Nimer, Stephen D.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784651/
https://ncbi.nlm.nih.gov/pubmed/23092893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003199
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