The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

Recent genome-wide association studies demonstrated that common variants of solute carrier family 30 member 8 gene (SLC30A8) increase susceptibility to type 2 diabetes. SLC30A8 encodes zinc transporter-8 (ZnT8), which delivers zinc ion from the cytoplasm into insulin granules. Although it is well kn...

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Hauptverfasser: Tamaki, Motoyuki, Fujitani, Yoshio, Hara, Akemi, Uchida, Toyoyoshi, Tamura, Yoshifumi, Takeno, Kageumi, Kawaguchi, Minako, Watanabe, Takahiro, Ogihara, Takeshi, Fukunaka, Ayako, Shimizu, Tomoaki, Mita, Tomoya, Kanazawa, Akio, Imaizumi, Mica O., Abe, Takaya, Kiyonari, Hiroshi, Hojyo, Shintaro, Fukada, Toshiyuki, Kawauchi, Takeshi, Nagamatsu, Shinya, Hirano, Toshio, Kawamori, Ryuzo, Watada, Hirotaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2013
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784536/
https://ncbi.nlm.nih.gov/pubmed/24051378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68807
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