Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse

Escape of prostate cancer (PCa) cells from ionizing radiation–induced (IR-induced) killing leads to disease progression and cancer relapse. The influence of sphingolipids, such as ceramide and its metabolite sphingosine 1-phosphate, on signal transduction pathways under cell stress is important to s...

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Autors principals: Cheng, Joseph C., Bai, Aiping, Beckham, Thomas H., Marrison, S. Tucker, Yount, Caroline L., Young, Katherine, Lu, Ping, Bartlett, Anne M., Wu, Bill X., Keane, Barry J., Armeson, Kent E., Marshall, David T., Keane, Thomas E., Smith, Michael T., Jones, E. Ellen, Drake, Richard R., Bielawska, Alicja, Norris, James S., Liu, Xiang
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784522/
https://ncbi.nlm.nih.gov/pubmed/24091326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64791
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