Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer

Radiation resistance in a subset of prostate tumors remains a challenge to prostate cancer radiotherapy. The current study on the effects of radiation on prostate cancer cells reveals that radiation programs an unpredicted resistance mechanism by upregulating acid ceramidase (AC). Irradiated cells d...

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Detalhes bibliográficos
Main Authors: Mahdy, Ayman EM, Cheng, Joseph C, Li, Jun, Elojeimy, Saeed, Meacham, William D, Turner, Lorianne S, Bai, Aiping, Gault, Christopher R, McPherson, Alex S, Garcia, Nicole, Beckham, Thomas H, Saad, Antonio, Bielawska, Alicja, Bielawski, Jacek, Hannun, Yusuf A, Keane, Thomas E, Taha, Mohhammed I, Hammouda, Hisham M, Norris, James S, Liu, Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835081/
https://ncbi.nlm.nih.gov/pubmed/19107118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.281
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