Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse

Escape of prostate cancer (PCa) cells from ionizing radiation–induced (IR-induced) killing leads to disease progression and cancer relapse. The influence of sphingolipids, such as ceramide and its metabolite sphingosine 1-phosphate, on signal transduction pathways under cell stress is important to s...

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Detalhes bibliográficos
Main Authors: Cheng, Joseph C., Bai, Aiping, Beckham, Thomas H., Marrison, S. Tucker, Yount, Caroline L., Young, Katherine, Lu, Ping, Bartlett, Anne M., Wu, Bill X., Keane, Barry J., Armeson, Kent E., Marshall, David T., Keane, Thomas E., Smith, Michael T., Jones, E. Ellen, Drake, Richard R., Bielawska, Alicja, Norris, James S., Liu, Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784522/
https://ncbi.nlm.nih.gov/pubmed/24091326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64791
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