Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through up-regulation of cathepsin B

Invasiveness is one of the key features of aggressive prostate cancer, however our understanding of the precise mechanisms effecting invasion remains limited. The ceramide hydrolyzing enzyme acid ceramidase (AC), overexpressed in most prostate tumors, causes an aggressive and invasive phenotype thro...

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Autori principali: Beckham, Thomas H., Lu, Ping, Cheng, Joseph C., Zhao, Dan, Turner, Lorianne S., Zhang, Xiaoyi, Hoffman, Stanley, Armeson, Kent E., Liu, Angen, Marrison, Tucker, Hannun, Yusuf A., Liu, Xiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384773/
https://ncbi.nlm.nih.gov/pubmed/22322590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27480
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