Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through up-regulation of cathepsin B

Invasiveness is one of the key features of aggressive prostate cancer, however our understanding of the precise mechanisms effecting invasion remains limited. The ceramide hydrolyzing enzyme acid ceramidase (AC), overexpressed in most prostate tumors, causes an aggressive and invasive phenotype thro...

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Detalhes bibliográficos
Main Authors: Beckham, Thomas H., Lu, Ping, Cheng, Joseph C., Zhao, Dan, Turner, Lorianne S., Zhang, Xiaoyi, Hoffman, Stanley, Armeson, Kent E., Liu, Angen, Marrison, Tucker, Hannun, Yusuf A., Liu, Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384773/
https://ncbi.nlm.nih.gov/pubmed/22322590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27480
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