Increased mammalian lifespan and a segmental and tissue-specific slowing of aging following genetic reduction of mTOR expression

We analyzed a new hypomorphic mouse model containing a targeted intronic insertion of a neomycin cassette within the mechanistic target of rapamycin (mTOR) locus. Mice with two hypomorphic (mTOR(Δ/Δ)) alleles are viable but express mTOR at approximately 25% of wild type levels. These animals demonst...

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Hoofdauteurs: Wu, J. Julie, Liu, Jie, Chen, Edmund B., Wang, Jennifer J., Cao, Liu, Narayan, Nisha, Fergusson, Marie M., Rovira, Ilsa I., Allen, Michele, Springer, Danielle A., Lago, Cory U., Zhang, Shuling, DuBois, Wendy, Ward, Theresa, deCabo, Rafael, Gavrilova, Oksana, Mock, Beverly, Finkel, Toren
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784301/
https://ncbi.nlm.nih.gov/pubmed/23994476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.030
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