Increased mammalian lifespan and a segmental and tissue-specific slowing of aging following genetic reduction of mTOR expression

We analyzed a new hypomorphic mouse model containing a targeted intronic insertion of a neomycin cassette within the mechanistic target of rapamycin (mTOR) locus. Mice with two hypomorphic (mTOR(Δ/Δ)) alleles are viable but express mTOR at approximately 25% of wild type levels. These animals demonst...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Wu, J. Julie, Liu, Jie, Chen, Edmund B., Wang, Jennifer J., Cao, Liu, Narayan, Nisha, Fergusson, Marie M., Rovira, Ilsa I., Allen, Michele, Springer, Danielle A., Lago, Cory U., Zhang, Shuling, DuBois, Wendy, Ward, Theresa, deCabo, Rafael, Gavrilova, Oksana, Mock, Beverly, Finkel, Toren
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784301/
https://ncbi.nlm.nih.gov/pubmed/23994476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.030
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker