Histone Deacetylase Inhibitor AR-42 Enhances E7-Specific CD8+ T Cell-Mediated Antitumor Immunity Induced by Therapeutic HPV DNA Vaccination

We have previously created a potent DNA vaccine encoding calreticulin linked to the HPV oncogenic protein E7 (CRT/E7). While treatment of the CRT/E7 DNA vaccine generates significant tumor-specific immune responses in vaccinated mice, the potency of the DNA vaccine could potentially be improved by c...

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Detalhes bibliográficos
Main Authors: Lee, Sung Yong, Huang, Zhuomin, Kang, Tae Heung, Soong, Ruey-Shyang, Knoff, Jayne, Axenfeld, Ellen, Wang, Chenguang, Alvarez, Ronald D., Chen, Ching-Shih, Hung, Chien-Fu, Wu, T.-C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783646/
https://ncbi.nlm.nih.gov/pubmed/23715898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-013-1054-9
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