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Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues
Huntington disease is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine (polyQ) expansion (> 35Q) in the first exon (EX1) of huntingtin protein (Htt). mHtt protein is thought to adopt one or more toxic conformation(s) that are involved in pathogenic interactions in cells...
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| Main Author: | |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Landes Bioscience
2013
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3783107/ https://ncbi.nlm.nih.gov/pubmed/23370273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.23807 |
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