Hypoxia triggers Hedgehog-mediated tumor stromal interactions in pancreatic cancer

Pancreatic cancer is characterized by a desmoplastic reaction that creates a dense fibroinflammatory microenvironment, promoting hypoxia and limiting cancer drug delivery due to decreased blood perfusion. Here we describe a novel tumor-stroma interaction that may help explain the prevalence of desmo...

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Detalhes bibliográficos
Main Authors: Spivak-Kroizman, Taly R., Hostetter, Galen, Posner, Richard, Aziz, Meraj, Hu, Chengcheng, Demeure, Michael J., Von Hoff, Daniel, Hingorani, Sunil R., Palculict, Timothy B., Izzo, Julie, Kiriakova, Galina M., Abdelmelek, Mena, Bartholomeusz, Geoffrey, James, Brian P., Powis, Garth
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782107/
https://ncbi.nlm.nih.gov/pubmed/23633488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1433
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