Hypoxia triggers Hedgehog-mediated tumor stromal interactions in pancreatic cancer

Pancreatic cancer is characterized by a desmoplastic reaction that creates a dense fibroinflammatory microenvironment, promoting hypoxia and limiting cancer drug delivery due to decreased blood perfusion. Here we describe a novel tumor-stroma interaction that may help explain the prevalence of desmo...

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Main Authors: Spivak-Kroizman, Taly R., Hostetter, Galen, Posner, Richard, Aziz, Meraj, Hu, Chengcheng, Demeure, Michael J., Von Hoff, Daniel, Hingorani, Sunil R., Palculict, Timothy B., Izzo, Julie, Kiriakova, Galina M., Abdelmelek, Mena, Bartholomeusz, Geoffrey, James, Brian P., Powis, Garth
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782107/
https://ncbi.nlm.nih.gov/pubmed/23633488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1433
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