Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF-2 in clear cell renal cell carcinoma

Clear cell kidney cancer (CRCC) is initiated typically by loss of the tumor suppressor VHL, driving constitutive activation of HIF-1 and HIF-2. However, whereas HIF-1 has a tumor suppressor role, HIF-2 plays a distinct role in driving CRCC. In this study, we show that the HIF-1α E3 ligase HAF comple...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cancer Res
Autori principali: Koh, Mei Yee, Nguyen, Vuvi, Lemos, Robert, Darnay, Bryant G., Kiriakova, Galina, Abdelmelek, Mena, Ho, Thai H., Karam, Jose, Monzon, Federico A., Jonasch, Eric, Powis, Garth
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297521/
https://ncbi.nlm.nih.gov/pubmed/25421578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2190
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi