Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF-2 in clear cell renal cell carcinoma

Clear cell kidney cancer (CRCC) is initiated typically by loss of the tumor suppressor VHL, driving constitutive activation of HIF-1 and HIF-2. However, whereas HIF-1 has a tumor suppressor role, HIF-2 plays a distinct role in driving CRCC. In this study, we show that the HIF-1α E3 ligase HAF comple...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Koh, Mei Yee, Nguyen, Vuvi, Lemos, Robert, Darnay, Bryant G., Kiriakova, Galina, Abdelmelek, Mena, Ho, Thai H., Karam, Jose, Monzon, Federico A., Jonasch, Eric, Powis, Garth
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297521/
https://ncbi.nlm.nih.gov/pubmed/25421578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2190
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