Insulin Receptor Phosphorylation by Endogenous Insulin or the Insulin Analog AspB10 Promotes Mammary Tumor Growth Independent of the IGF-I Receptor

Endogenous hyperinsulinemia and insulin receptor (IR)/IGF-I receptor (IGF-IR) phosphorylation in tumors are associated with a worse prognosis in women with breast cancer. In vitro, insulin stimulation of the IR increases proliferation of breast cancer cells. However, in vivo studies demonstrating th...

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Autori principali: Gallagher, Emily Jane, Alikhani, Nyosha, Tobin-Hess, Aviva, Blank, Jeffrey, Buffin, Nicholas J., Zelenko, Zara, Tennagels, Norbert, Werner, Ulrich, LeRoith, Derek
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2013
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781483/
https://ncbi.nlm.nih.gov/pubmed/23835331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0249
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